Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 12 0.0 0.577 0.141 0.152
biological_process el 12 0.321 0.91 0.69 0.183
biological_process ka 12 0.0 0.613 0.129 0.164
biological_process rf 12 0.0 0.577 0.141 0.152
cellular_component ct 12 0.001 0.812 0.259 0.223
cellular_component el 12 0.056 0.956 0.54 0.319
cellular_component ka 12 0.003 0.814 0.259 0.226
cellular_component rf 12 0.0 0.812 0.259 0.223
disease ct 5 0.002 0.945 0.323 0.401
disease el 5 0.005 0.935 0.206 0.365
disease ka 5 0.0 0.741 0.287 0.343
disease rf 5 0.002 0.943 0.323 0.401
genetic_interaction ct 8 0.016 0.88 0.454 0.317
genetic_interaction el 8 0.009 0.885 0.459 0.321
genetic_interaction ka 8 0.041 0.197 0.132 0.051
genetic_interaction rf 8 0.016 0.88 0.454 0.317
molecular_function ct 12 0.0 0.884 0.332 0.304
molecular_function el 12 0.166 0.954 0.609 0.285
molecular_function ka 12 0.0 0.893 0.328 0.307
molecular_function rf 12 0.0 0.884 0.335 0.303
pathway ct 3 0.055 0.202 0.123 0.06
pathway el 3 0.002 0.151 0.092 0.065
pathway ka 3 0.002 0.127 0.059 0.051
pathway rf 3 0.037 0.157 0.088 0.051
phenotype ct 5 0.001 0.229 0.088 0.098
phenotype el 5 0.224 0.645 0.473 0.159
phenotype ka 5 0.001 0.22 0.107 0.09
phenotype rf 5 0.001 0.229 0.088 0.098
protein_interaction ct 12 0.0 0.349 0.067 0.108
protein_interaction el 12 0.0 0.39 0.058 0.107
protein_interaction ka 12 0.0 0.032 0.006 0.009
protein_interaction rf 12 0.0 0.325 0.065 0.104

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 12 0.0 0.728 0.289 0.279
integration_mean_by_presence el 12 0.015 0.855 0.31 0.233
integration_mean_by_presence ka 12 0.0 0.77 0.197 0.221
integration_mean_by_presence rf 12 0.001 0.32 0.061 0.096
mean ct 12 0.0 0.788 0.235 0.277
mean el 12 0.002 0.743 0.234 0.204
mean ka 12 0.0 0.392 0.131 0.141
mean rf 12 0.0 0.323 0.062 0.1

CDF plots of non integrated kernels

CDF plots of integrated kernels